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Emerging therapies

Emerging therapies

Blood–brain barrier best breached by small molecules

30 Oct 2019
FUS-mediated BBB opening
Fluorescence images of mice after FUS-mediated BBB opening at three pressures (top to bottom): 0.42, 0.26 and 0.18 MPa. Images show signal from 3 kDa (blue), 70 kDa (red) and 500 kDa (green) dextran molecules. (Courtesy: M A Valdez et al Ultrasound Med. Biol. 10.1016/j.ultrasmedbio.2019.08.024)
Focused ultrasound (FUS) can be used to help drugs pass from the bloodstream into the brain, but the

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Marric Stephens is a freelance science writer based in Bristol, UK
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